Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice
作者： Hongwei Wang , Madhukumar Venkatesh , Hao Li , Regina Goetz , Subhajit Mukherjee
DOI: 10.1172/JCI41514
关键词: Cell growth 、 Colorectal cancer 、 Internal medicine 、 Biology 、 Cancer cell 、 Cancer research 、 Cell type 、 Receptor 、 Metastasis 、 Endocrinology 、 Nuclear receptor 、 Pregnane X receptor
摘要: … (eg, colon, breast, and ovary) (15–19). In search of tissue-specific functions of PXR, we previously demonstrated that PXR activation induces ovarian cancer cell proliferation and drug …
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