Gut barrier dysfunction treatment and prevention

作者: Sridhar Mani , Subhajit Mukherjee

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摘要: Methods are disclosed for treating and preventing gut barrier dysfunction or an illness associated with in a subject comprising administering to the bacterium that produce indole metabolite identifying compounds bacteria use treatment prevention of dysfunction.

参考文章(42)
Douglas C. Murdock, Enhanced indole biosynthesis ,(1993)
Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles. Scientific Reports. ,vol. 5, pp. 12689- 12689 ,(2015) , 10.1038/SREP12689
Mary Carmen Valenzano, Katherine DiGuilio, Joanna Mercado, Mimi Teter, Julie To, Brendan Ferraro, Brittany Mixson, Isabel Manley, Valerissa Baker, Beverley A. Moore, Joshua Wertheimer, James M. Mullin, Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0133926
Martina Brave, Dana J. Lukin, Sridhar Mani, Microbial control of intestinal innate immunity. Oncotarget. ,vol. 6, pp. 19962- 19963 ,(2015) , 10.18632/ONCOTARGET.4780
Hideo Satsu, Yuto Hiura, Keiichi Mochizuki, Mika Hamada, Makoto Shimizu, Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals Journal of Agricultural and Food Chemistry. ,vol. 56, pp. 5366- 5373 ,(2008) , 10.1021/JF073350E
Hinrich Gronemeyer, Jan-Åke Gustafsson, Vincent Laudet, Principles for modulation of the nuclear receptor superfamily Nature Reviews Drug Discovery. ,vol. 3, pp. 950- 964 ,(2004) , 10.1038/NRD1551
Gordana Zavisic, Jelena Begovic, Ivana Strahinic, Ljubisa Topisirovic, Zeljka Radulovic, Sasa Petricevic, Natasa Golic, Probiotic features of two oral Lactobacillus isolates Brazilian Journal of Microbiology. ,vol. 43, pp. 418- 428 ,(2012) , 10.1590/S1517-838220120001000050
B. Blumberg, R. M. Evans, Orphan nuclear receptors—new ligands and new possibilities Genes & Development. ,vol. 12, pp. 3149- 3155 ,(1998) , 10.1101/GAD.12.20.3149
David J. Waxman, P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR Archives of Biochemistry and Biophysics. ,vol. 369, pp. 11- 23 ,(1999) , 10.1006/ABBI.1999.1351
Hongwei Wang, Madhukumar Venkatesh, Hao Li, Regina Goetz, Subhajit Mukherjee, Arunima Biswas, Liang Zhu, Andreas Kaubisch, Lei Wang, James Pullman, Kathleen Whitney, Makoto Kuro-o, Andres I. Roig, Jerry W. Shay, Moosa Mohammadi, Sridhar Mani, Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice Journal of Clinical Investigation. ,vol. 121, pp. 3220- 3232 ,(2011) , 10.1172/JCI41514