A new mouse model for evaluating the immunotherapy of human colorectal cancer
作者： Raju Kucherlapati , Heidi Hörig , Winfried Edelmann , Howard L. Kaufman , Akiva Marcus
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摘要: A new murine model of human colorectal cancer was generated by crossing carcinoembryonic antigen (CEA) transgenic mice (H-2Kb) with adenomatous polyposis coli (Apc1638N) knockout (H-2Kb). The resulting hybrid developed gastrointestinal polyps in 6–8 months that progressed to invasive carcinomas a similar pattern dysplasia and CEA expression as observed cancer. These animals exhibited incomplete or partial tolerance evidenced delayed growth CEA-expressing tumors the inability inhibit CEA-specific CTL responses. results have important implications for understanding role immunity colon patients suggest vaccine strategies targeting may be feasible. This provides powerful system evaluating antigen-specific tumor against spontaneous arising an orthotopic location permits evaluation therapeutic
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