A mouse model of human familial adenomatous polyposis.
作者： Kan Yang , Winfried Edelmann , Kunhua Fan , Kirkland Lau , Venkateswara R. Kolli
DOI: 10.1002/(SICI)1097-010X(19970215)277:3<245::AID-JEZ5>3.0.CO;2-O
关键词:
摘要: In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry mutation in the adenomatous polyposis coli (Apc) gene. Mice are heterozygous mutation, designated Apc1638, develop colonic polyps and tumors of small intestine. Neoplasms were found 96% animals studied, they included adenomas, adenocarcinomas, polypoid hyperplasias. The developed average 3.3 tumors, with highest number duodenum, followed by jejunum, stomach, ileum, colon. Focal areas dysplasias observed mucosa 50% 10 months old or older. These results suggest that carrying Apc1638 can serve as study initiation, progression, inhibition gastrointestinal tumors.
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