Phase I Study in Advanced Cancer Patients of a Diversified Prime-and-Boost Vaccination Protocol Using Recombinant Vaccinia Virus and Recombinant Nonreplicating Avipox Virus to Elicit Anti–Carcinoembryonic Antigen Immune Responses

作者: John L. Marshall , Robert J. Hoyer , Mary Ann Toomey , Kristen Faraguna , Ping Chang

DOI: 10.1200/JCO.2000.18.23.3964

关键词: ImmunotherapyVirologyTumor antigenMedicineActive immunizationRecombinant virusInterferon-gamma productionCarcinoembryonic antigenVacciniaOrthopoxvirusImmunology

摘要: PURPOSE: This trial sought to determine, for the first time, validity in human vaccinations of using two different recombinant vaccines diversified prime-and-boost regimens enhance T-cell responses a tumor antigen. PATIENTS AND METHODS: Eighteen patients with advanced tumors expressing carcinoembryonic antigen (CEA) were randomized receive either vaccinia (rV)-CEA followed by three avipox-CEA vaccinations, or (three times) one rV-CEA vaccination. Subsequent both cohorts avipox-CEA. Immunologic monitoring was performed CEA peptide and enzyme-linked immunospot assay interferon gamma production. RESULTS: superior reverse order generation CEA-specific responses. Further increases precursors seen when local granulocyte-macrophage colony-stimulating factor (GM-CSF) low-dose interleukin (IL)-2 given subsequent vaccinations...

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