Preclinical models for chemoprevention of colon cancer.
作者： Eugene W. Gerner , Natalia A. Ignatenko , David G. Besselsen
DOI: 10.1007/978-3-642-55647-0_6
关键词:
摘要: Colon cancer is the second leading cause of incidence and death in USA 2002. Specific genetic defects have been identified which hereditary colon cancers humans. In addition, a number intestinal luminal risk factors for described. This information has exploited to develop experimental cell rodent models recapitulate feature s human cancer. this chapter, we will discuss strengths limitations these further our understanding basic mechanisms carcinogenesis strategies chemoprevention.
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