Aging-associated changes in murine intestinal immunoglobulin A and M secretions.

摘要: The aging effect on the quantity of intestinal IgA and IgM class-specific immunoglobulins secreted quality intraluminal was studied in 5-to 6-month old 24-to 28-month-old male BALB/c mice. level increased juice from aged mice, while remained unchanged. These alterations were similar to those found serum, but age serum profound, almost a threefold increase, contrast, an increase just under 35% secretions. ratio dimeric total small intestine decreased older though that In amounts lavage fluid did not change between two groups, mice 4.5 times as high young binding purified antigens normal habitant enteric bacteria (γ streptococci Enterobacter agglomerans) declined immunochemical studies, using SDS-PAGE isoelectric focusing, showed no major difference. Thus, findings perfusates content is due monomeric IgA, reduced which remains unchanged, capacity bacterial diminished, suggest matural secretory antibody decreased. altered quantitative functional features observed appear be complex heterogeneous effects senescence gut-associated lymphoid tissues, may contribute age-related impairment gut humoral immune function.