Role of mesenteric lymph nodes and aging in secretory IgA production in mice.
作者： A.F. Santiago , R.M. Fernandes , B.P. Santos , F.A. Assis , R.P. Oliveira
DOI: 10.1016/J.CELLIMM.2008.06.004
关键词: Cytokine 、 Lamina propria 、 Immunoglobulin G 、 Immunology 、 Mesenteric lymph nodes 、 B-1 cell 、 Spleen 、 Immunoglobulin M 、 Immunoglobulin class switching 、 Biology
摘要: Although it is known that Peyer's patches are the major inductive site for S-IgA production and B1 cells contribute to half of IgA plasma detected in gut lamina propria, type contribution mesenteric lymph nodes process still unclear. Cytokines such as TGF-beta, IL-10, IL-4, IL-5, IL-6, required promote class switching synthesis. Aging-related alterations T B cytokine already known. Some reports have also proposed might be altered aged animals. Herein, we investigated role MLN aging production. Two- 18-month-old BALB/c mice were used evaluate aging-related removed study its We found important, although not essential In addition, showed IgA-related cytokines well preserved but PP levels affected by aging. Our results suggest may play a complementary mostly
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