Differential effect of aging on the heterogeneity of the immune response to a T-dependent antigen in systemic and mucosal-associated lymphoid tissues.

摘要: The heterogeneity of the immune response in various lymphatic sites to trinitrophenylated bovine gamma-globulin was measured old and young mice at a cellular level using inhibition plaque-forming cell assay. primary splenic PFC C57BL/6J male found be markedly restricted heterogeneity, with preferential loss IgM, IgG, IgA high avidity PFC. draining peripheral lymph node IgG exhibited similar restriction In contrast, mesenteric mediastinal remained highly heterogeneous respect antibody affinity 3 isotypes studied. These results support hypothesis that mucosal-associated lymphoid system differs from systemic regard its competence age. Furthermore, imply T helper activity is unimpaired apparatus aged animals.