Stoffwechselprodukte von Mikroorganismen 143. Mitteilung. Echinocandin B, ein neuartiges Polypeptid‐Antibioticum aus Aspergillus nidulans var. echinulatus: Isolierung und Bausteine
作者： Fritz Benz , Fritz Knüsel , Jakob Nüesch , Hansjörg Treichler , Walter Voser
关键词: Strain (chemistry) 、 Stereochemistry 、 Hydrolytic degradation 、 Chemistry 、 Aspergillus nidulans 、 Echinocandin 、 Polypeptide antibiotic 、 Echinocandin B
摘要: From a strain of Aspergillus nidulans var. echinulatus, A 32204, echinocandin, novel polypeptide antibiotic complex with high and specific anti-yeast activity was isolated. The main component, echinocandin B, separated by counter-current distribution. tentative molecular formula C52H81N7O18 is discussed. characterized its IR. NMR. spectra characteristic hydrolytic degradation products: linoilic acid, L-4-hydroxyproline, L-4-oxoproline, (2S, 3S, 4S)-4-methyl-3-hydroxy-proline, L-threonine (2 mols), 1-(p-hydroxyphenyl)-3-amino-propan-2-one.
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