Bioequivalence and absolute bioavailability of oblong and coated levomepromazine tablets in CYP2D6 phenotyped subjects
作者： U Barlage , G Höflich , S Kasper , H J Möller , M Bagli
DOI:
关键词: Dextromethorphan 、 Chromatography 、 Medicine 、 Bioavailability 、 Levomepromazine 、 Pharmacokinetics 、 Volume of distribution 、 Pharmacology 、 Oral administration 、 Bioequivalence 、 Cmax
摘要: The bioequivalence and absolute bioavailability of oblong and coated levomepromazine tablets were studied in 12 healthy volunteers. A 1-hour intravenous infusion served as the reference. Serum concentrations of levomepromazine were quantified with a specific high-performance liquid chromatographic method and electrochemical detection. The 2 oral formulations were bioequivalent. After oral administration of oblong and coated levomepromazine tablets the mean serum concentration versus time profiles were similar …
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