Validation of Mechanistic Models

U Barlage, G Höflich, S Kasper, H J Möller, M Bagli, P Baumann, M Kolbinger, M Langer, M L Rao, Bioequivalence and absolute bioavailability of oblong and coated levomepromazine tablets in CYP2D6 phenotyped subjects International Journal of Clinical Pharmacology and Therapeutics. ,vol. 33, pp. 646- 652 ,(1995)

K. Sugano, 5.19 – Artificial Membrane Technologies to Assess Transfer and Permeation of Drugs in Drug Discovery Comprehensive Medicinal Chemistry II. ,vol. 5, pp. 453- 487 ,(2007) , 10.1016/B0-08-045044-X/00136-X

Ching‐Yuan Li, Cheryl L. Zimmerman, Timothy S. Wiedmann, Diffusivity of bile salt/phospholipid aggregates in mucin. Pharmaceutical Research. ,vol. 13, pp. 535- 541 ,(1996) , 10.1023/A:1016085719058

Makoto Kataoka, Yoshie Masaoka, Yukako Yamazaki, Toshiyasu Sakane, Hitoshi Sezaki, Shinji Yamashita, In Vitro System to Evaluate Oral Absorption of Poorly Water-Soluble Drugs: Simultaneous Analysis on Dissolution and Permeation of Drugs Pharmaceutical Research. ,vol. 20, pp. 1674- 1680 ,(2003) , 10.1023/A:1026107906191

Win L. Chiou, Paul W. Buehler, Comparison of Oral Absorption and Bioavailability of Drugs Between Monkey and Human Pharmaceutical Research. ,vol. 19, pp. 868- 874 ,(2002) , 10.1023/A:1016169202830

E. Galia, E. Nicolaides, D. Hörter, R. Löbenberg, C. Reppas, J. B. Dressman, Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs Pharmaceutical Research. ,vol. 15, pp. 698- 705 ,(1998) , 10.1023/A:1011910801212

Sunanda A. Ranadive, Andrew X. Chen, Abu T. M. Serajuddin, Relative lipophilicities and structural-pharmacological considerations of various angiotensin-converting enzyme (ACE) inhibitors. Pharmaceutical Research. ,vol. 9, pp. 1480- 1486 ,(1992) , 10.1023/A:1015823315983

Win L. Chiou, Hyun Y. Jeong, Sang M. Chung, Ta C. Wu, Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans. Pharmaceutical Research. ,vol. 17, pp. 135- 140 ,(2000) , 10.1023/A:1007552927404

Win L. Chiou, Abhijit Barve, Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats. Pharmaceutical Research. ,vol. 15, pp. 1792- 1795 ,(1998) , 10.1023/A:1011981317451

Tanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Tami L. O’Sullivan, John G. Wagner, Jennifer B. Dressman, pH-Related Changes in the Absorption of Dipyridamole in the Elderly Pharmaceutical Research. ,vol. 11, pp. 136- 143 ,(1994) , 10.1023/A:1018918316253