CTHRSSVVC Peptide as a Possible Early Molecular Imaging Target for Atherosclerosis
作者： Rosemeire A Silva , Ricardo J Giordano , Paulo S Gutierrez , Viviane Z Rocha , Martina Rudnicki
DOI: 10.3390/IJMS17091383
关键词: Molecular biology 、 Lipoprotein 、 Phage display 、 Peptide 、 In vitro 、 Atheroma 、 Receptor 、 CD163 、 Biology 、 Growth factor
摘要: The purpose of our work was to select phages displaying peptides capable binding vascular markers present in human atheroma, and validate their capacity target the vitro low-density lipoprotein receptor knockout (LDLr−/−) mouse model atherosclerosis. By peptide fingerprinting on atherosclerotic tissues, we selected isolated four different sequences, which bind lesions share significant similarity known proteins with prominent roles CTHRSSVVC-phage displayed strongest reactivity carotid (p 95% yield as determined by high performance liquid chromatography (HPLC), plaque specimens. results supported hypothesis that CTHRSSVVC has a remarkable sequence for development theranostics approaches treatment atherosclerosis other diseases.
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