The Hypertension Optimal Treatment Study (The HOT Study)

摘要: The Hypertension Optimal Treatment (HOT) Study is a prospective, randomized, multicenter study which will be conducted in some 20 countries world-wide. Two major issues investigated: i) What the optimal target diastolic blood pressure duringantihypertensive treatment with regard to thereduction cardiovascular morbidity and mortality? In order address this question patients randomized three different therapeutic goals: <90 mmHg, g85 mmHg or < 80 mmHg; ii) second aim evaluate effect of low dose acetylsalicylic acid (ASA, aspirin) 75 mg 0.d. comparison placebo on mortality. first investigated accordance PROBE design (Prospective Randomized Open Blinded Endpoint evaluation), whereas evaluation aspirin versus under double blind conditions. It estimated that 1.100 clinical events needed answer regarding relationship between events. collection these require enrolment at least 18,000 hypertensive men women aged 50-80 years followed for 2.5 (about 40,000 patient years). All given felodipine 5 as basic antihypertensive addition 8-blocker an ACEinhibitor step, further predetermined increments dosage required obtain