Inducible epitope imprinting: 'generating' the required binding site in membrane receptors for targeted drug delivery.
作者： Sha Liu , Qiuyan Bi , Yingying Long , Zhuoxuan Li , Sanjib Bhattacharyya
DOI: 10.1039/C6NR09449J
关键词: Epitope 、 Cell biology 、 Imprinting (psychology) 、 Biology 、 Molecular imprinting 、 Targeted drug delivery 、 Biochemistry 、 Cell surface receptor 、 Binding site 、 Peptide 、 Conformational change
摘要: We report an inducible epitope imprinting strategy that as a template, flexible peptide chain can have disordered-to-ordered conformational change by suitable inducement through molecular procedure, and the formed nanoparticles can, in turn, remold original into expected conformation specifically bind to corresponding protein.
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