Second malignant neoplasms after cancer in childhood or adolescence. Nordic Society of Paediatric Haematology and Oncology Association of the Nordic Cancer Registries.

摘要: OBJECTIVE--To assess the relative risk of developing a second malignant neoplasm in people with diagnosis cancer childhood and adolescence. DESIGN--Register based follow up study. SETTING--Populations Nordic countries. SUBJECTS--30,880 under age 20 first diagnosed during period 1943-87. MAIN OUTCOME MEASURES--Relative attributable risks neoplasms by type cancer, at diagnosis, calendar period, sex, country. Expected figures were on appropriate national incidence rates for cancer. RESULTS--247 cases observed 238 patients, yielding 3.6 (95% confidence interval 3.1 to 4.1). The changed significantly from 2.6 1940s 1950s 6.9 among cohort members included late 1970s 1980s. Increases most types Highest levels seen 10 years immediately after diagnosis. associated treatments, however, showed consistent rise throughout 45 up. CONCLUSION--The estimated lower than those found large hospital studies but compatible results similar population study United Kingdom. Extent pattern countries are believed be representative part European population.