A clinical trial testing the efficacy of PDT in preventing amputation in diabetic patients.

摘要: The feet of diabetic patients continue to be an unsolved problem in medicine. Uncontrolled neuropathy, ulceration and infection usually lead amputation presently there is no effective reliable method that can used provide efficient cure. Overall improvement the salvage strategies, based on comprehensive pre-clinical evaluation, debridement, antibiotic therapy follow up, has shown improvements certain hospital settings, but general picture for with foot have some sort amputation, especially underserved populations. It clearly necessary develop novel treatment strategies this worldwide health problem. Photodynamic (PDT) a modality uses light generate situ reactive oxygen species, which cause cell death. PDT treat several diseases, including infections do not respond well therapy. There are characteristics make it potentially ideal feet: photosensitizer non-toxic dark, after illumination becomes very antimicrobial agent topical use, regenerate small bones, such as phalanges. However, still clinical practice feet. Therefore, we decided perform study prove avoid infected An inexpensive protocol was developed applied 18 osteomyelitis, classified Grade 3 Wagner scale. Only one these suffered amputation. At least two them were cured from resistant bacteria strains without intravenous In control group 16 patients, all ended up suffering rate 0.029 times difference statistically significant (p=0.002).