Endothelial Cell Dysfunction and Oxidative Stress

摘要: Publisher Summary This chapter reviews findings relevant to endothelial cell biology in preeclampsia. Endothelial dysfunction preeclampsia results a variety of circulating factors, such as angiogenic metabolic and inflammatory mediators. activation or damage is manifest biochemically by the synthesis secretion products including prostanoids, endothelin-1 (ET-1), platelet-derived growth factor (PDGF), fibronectin, selectins, other molecules that influence vessel tone remodeling. When activated chronic pathological process, preeclampsia, these responses can create vicious cycle vasospasm, microthrombosis, disruption vascular integrity, serious physiologic disturbances which persist until inciting factor(s) eliminated. Evidence suggests pathogenesis involves plasma constituents induce and/or dysfunction. Given understanding epidemiology this disease, it highly probable placenta contributes factors responsible for In addition, considerable evidence maternal constitutional also are involved.