Neutrophil CD11B expression and neutrophil activation in pre-eclampsia.

摘要: 1. Neutrophil activation was examined in 22 women with pre-eclampsia and age- gestation-matched control subjects using whole-blood flow cytometry to assess basal platelet-activating factor stimulated CD11b CD18. 2. Basal neutrophil expression significantly increased compared normal pregnancy before delivery. A similar non-significant trend for CD18 also observed. 3. Before delivery, a dose-dependent fashion after stimulation, the differences between groups maintained. increase observed factor. 4. There were no between-group of either or at 6 weeks months post partum, stimulation. 5. positively correlated plasma uric acid (r = 0.44, P 0.04) pre-eclampsia, suggesting that extent correlates disease severity. 6. An is likely be an index vivo. release free radicals proteases may then help perpetuate vicious cycle endothelial vascular dysfunction placental systemic circulations. The cause this not known but could involve platelet activation, production endothelin-1 cytokines. Further studies will required elucidate consequences pre-eclampsia.