Incidence of new-onset autoimmune disease in girls and women with pre-existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study

摘要: Objective To assess whether quadrivalent human papillomavirus (qHPV) vaccination is associated with increased incidence of new-onset autoimmune disease in girls and women pre-existing disease. Methods This register-based open cohort study included all between 10 30 years age Sweden 2006–2012 diagnosed at least one 49 prespecified diseases (n = 70 265). Incidence rate ratios were estimated for within 180 days qHPV using Poisson regression adjusting for, country birth, parental income education. Results A total 265 had the predefined diseases; 16% these individuals received dose vaccine. In unvaccinated women, 5428 observed during 245 807 person-years a 22.1 (95% CI 21.5–22.7) new events per 1000 person-years. vaccinated there 124 7848 15.8 13.2–18.8) There was no increase risk period; on contrary, we found slightly reduced (incidence ratio 0.77, 95% 0.65–0.93). Conclusion In this nationwide study, not disease.