‘One-pot’ nitro reduction–cyclisation solid phase route to benzimidazoles
作者： Zemin Wu , Philip Rea , Geoffrey Wickham
DOI: 10.1016/S0040-4039(00)01732-9
关键词: Benzimidazole 、 Solid-phase synthesis 、 Nitro reduction 、 Chemistry 、 Organic chemistry
摘要: An improved solid phase synthesis of benzimidazoles is described. A polymer-bound o-nitroaniline was reacted with aldehydes in DMF the presence SnCl2·2H2O at 60°C for three hours to give excellent purity and good yield after TFA cleavage. library 25 prepared using this ‘one-pot’ procedure.
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