Multifunctional core-shell nanoparticles as highly efficient imaging and photosensitizing agents.
作者： Ruirui Zhang , Chuanliu Wu , Lili Tong , Bo Tang , Qing-Hua Xu
DOI: 10.1021/LA902235D
关键词: Nanoparticle 、 Fluorescence-lifetime imaging microscopy 、 Nanoreactor 、 Mesoporous silica 、 Nanocomposite 、 Hematoporphyrin 、 Materials science 、 Photosensitizing Agent 、 Nanotechnology 、 Photosensitizer
摘要: Here we report the preparation of a novel multifunctional core−shell nanocomposite material that contains nonporous dye-doped silica core and mesoporous shell containing photosensitizer molecules, hematoporphyrin (HP). This architecture allows simultaneous fluorescence imaging photosensitization treatment. The molecules are covalently linked to exhibit excellent photo-oxidation efficiency. efficiency hybrid nanoparticles was demonstrated be significantly improved over in homogeneous solution. nanovehicle acts not only as carrier for photosensitizers but also nanoreactor facilitate reaction. doping dyes into endows capability, which has been with cell experiments. approach could easily extended conjugate other functional regents if necessary. These multifu...
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sci-hub.se 参考文章(44)
X. Zhao, R. P. Bagwe, W. Tan, Development of Organic‐Dye‐Doped Silica Nanoparticles in a Reverse Microemulsion Advanced Materials. ,vol. 16, pp. 173- 176 ,(2004) , 10.1002/ADMA.200305622
Christophe Cantau, Thierry Pigot, Narayanapillai Manoj, Esther Oliveros, Sylvie Lacombe, Singlet Oxygen in Microporous Silica Xerogel: Quantum Yield and Oxidation at the Gas–Solid Interface ChemPhysChem. ,vol. 8, pp. 2344- 2353 ,(2007) , 10.1002/CPHC.200700482
María Vallet-Regí, Francisco Balas, Daniel Arcos, Mesoporous materials for drug delivery. Angewandte Chemie. ,vol. 46, pp. 7548- 7558 ,(2007) , 10.1002/ANIE.200604488
Chuanliu Wu, Chen Chen, Jinping Lai, Jianbin Chen, Xue Mu, Jinsheng Zheng, Yibing Zhao, Molecule-scale controlled-release system based on light-responsive silica nanoparticles. Chemical Communications. pp. 2662- 2664 ,(2008) , 10.1039/B804886J
Rahul P. Bagwe, Chaoyong Yang, Lisa R. Hilliard, Weihong Tan, Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method Langmuir. ,vol. 20, pp. 8336- 8342 ,(2004) , 10.1021/LA049137J
Ron Hardman, A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environmental Health Perspectives. ,vol. 114, pp. 165- 172 ,(2006) , 10.1289/EHP.8284
Lixin Shi, Billy Hernandez, Matthias Selke, Singlet Oxygen Generation from Water-Soluble Quantum Dot-Organic Dye Nanocomposites Journal of the American Chemical Society. ,vol. 128, pp. 6278- 6279 ,(2006) , 10.1021/JA057959C
Tymish Y. Ohulchanskyy, Indrajit Roy, Lalit N. Goswami, Yihui Chen, Earl J. Bergey, Ravindra K. Pandey, Allan R. Oseroff, Paras N. Prasad, Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer Nano Letters. ,vol. 7, pp. 2835- 2842 ,(2007) , 10.1021/NL0714637
Dayane B. Tada, Lucas L. R. Vono, Evandro L. Duarte, Rosangela Itri, Pedro K. Kiyohara, Maurício S. Baptista, Liane M. Rossi, Methylene Blue-Containing Silica-Coated Magnetic Particles: A Potential Magnetic Carrier for Photodynamic Therapy Langmuir. ,vol. 23, pp. 8194- 8199 ,(2007) , 10.1021/LA700883Y
Barbara A. Lindig, Michael A. J. Rodgers, A. Paul Schaap, Determination of the lifetime of singlet oxygen in water-d2 using 9,10-anthracenedipropionic acid, a water-soluble probe Journal of the American Chemical Society. ,vol. 102, pp. 5590- 5593 ,(1980) , 10.1021/JA00537A030