Does immediate breast reconstruction using free flaps lead to delay in the administration of adjuvant chemotherapy for breast cancer

作者: M. Kontos , R.S. Lewis , M. Lüchtenborg , L. Holmberg , H. Hamed

DOI: 10.1016/J.EJSO.2010.06.013

关键词: Free flapBreast cancerAdjuvantAdjuvant chemotherapySurgeryBreast reconstructionAdjuvant therapyMastectomyMedicineLead (electronics)

摘要: Abstract Background Immediate breast reconstruction (IBR) using Free flaps is becoming increasingly popular. However, these are complex surgical procedures with more complications and longer recovery time, which can potentially delay adjuvant treatment. Our aim to investigate the impact of free flap IBR on timing Methods Details all cancer patients undergoing mastectomy (study group) without (control IBR, followed by treatment between 2002 2007 were obtained. The time lapse surgery therapy was calculated causes recorded. results compared two groups local international guidelines. Results Twenty-seven 139 included in study control group, respectively. mean period commencement for group 55 days 40 controls. Furthermore, significantly less received their within 6, 8 or 10 weeks after comparison group. Groups appeared similar however at 12-week point. reason delays reconstruction-related complications. Conclusion There a significant alone due related effects this survival have not been fully investigated yet may be least some patients.

参考文章(27)
Abram Recht, Stephen B. Edge, Lawrence J. Solin, David S. Robinson, Alison Estabrook, Richard E. Fine, Gini F. Fleming, Silvia Formenti, Clifford Hudis, Jeffrey J. Kirshner, David A. Krause, Robert R. Kuske, Amy S. Langer, George W. Sledge, Timothy J. Whelan, David G. Pfister, Postmastectomy Radiotherapy: Clinical Practice Guidelines of the American Society of Clinical Oncology* Journal of Clinical Oncology. ,vol. 19, pp. 1539- 1569 ,(2001) , 10.1200/JCO.2001.19.5.1539
Marga F. Massey, Aldona J. Spiegel, Joshua L. Levine, James E. Craigie, Richard M. Kline, Kamran Khoobehi, Heather Erhard, David T. Greenspun, Robert J. Allen, Robert J. Allen, Perforator flaps: recent experience, current trends, and future directions based on 3974 microsurgical breast reconstructions. Plastic and Reconstructive Surgery. ,vol. 124, pp. 737- 751 ,(2009) , 10.1097/PRS.0B013E3181B17A56
M.M.B Kay, CYTO-TOXIC CHEMOTHERAPY IN BREAST-CANCER - REPLY The Lancet. ,vol. 1, pp. 459- 459 ,(1975) , 10.1016/S0140-6736(75)90877-6
Marco Colleoni, Marco Bonetti, Alan S. Coates, Monica Castiglione-Gertsch, Richard D. Gelber, Karen Price, Carl-Magnus Rudenstam, Jurij Lindtner, John Collins, Beat Thürlimann, Stig Holmberg, Andrea Veronesi, Giovanni Marini, Aron Goldhirsch, , Early Start of Adjuvant Chemotherapy May Improve Treatment Outcome for Premenopausal Breast Cancer Patients With Tumors not Expressing Estrogen Receptors Journal of Clinical Oncology. ,vol. 18, pp. 584- 590 ,(2000) , 10.1200/JCO.2000.18.3.584
R. S. Lewis, M. Kontos, Autologous tissue immediate breast reconstruction: desired but oncologically safe? International Journal of Clinical Practice. ,vol. 63, pp. 1642- 1646 ,(2009) , 10.1111/J.1742-1241.2009.02199.X
Carlos Jara Sánchez, Amparo Ruiz, Miguel Martín, Antonio Antón, Blanca Munárriz, Arrate Plazaola, José Schneider, Purificación Martínez del Prado, Emilio Alba, Antonio Fernández-Aramburo, Influence of timing of initiation of adjuvant chemotherapy over survival in breast cancer: a negative outcome study by the Spanish Breast Cancer Research Group (GEICAM). Breast Cancer Research and Treatment. ,vol. 101, pp. 215- 223 ,(2007) , 10.1007/S10549-006-9282-0
Tanir M Allweis, Marc E Boisvert, Susan E Otero, David J Perry, Norman H Dubin, Dennis A Priebat, Immediate reconstruction after mastectomy for breast cancer does not prolong the time to starting adjuvant chemotherapy. American Journal of Surgery. ,vol. 183, pp. 218- 221 ,(2002) , 10.1016/S0002-9610(02)00793-6
David G Pennington, BREAST RECONSTRUCTION AFTER MASTECTOMY: CURRENT STATE OF THE ART Anz Journal of Surgery. ,vol. 75, pp. 454- 458 ,(2005) , 10.1111/J.1445-2197.2005.03384.X
C. Shannon, S. Ashley, I.E. Smith, Does Timing of Adjuvant Chemotherapy for Early Breast Cancer Influence Survival Journal of Clinical Oncology. ,vol. 21, pp. 3792- 3797 ,(2003) , 10.1200/JCO.2003.01.073