Testing for glaucoma with frequency-doubling perimetry in normals, ocular hypertensives, and glaucoma patients.

作者: Folkert K. Horn , Nina Wakili , Anselm M. Jünemann , Matthias Korth

DOI: 10.1007/S00417-002-0512-9

关键词: PerimeterVisual fieldOptometryOphthalmologyOcular hypertensionGlaucomaSingle testFrequency doubling perimetryEye diseaseReproducibilityMedicine

摘要: Abstract Background. The aim of this study was to evaluate the diagnostic usefulness FDT perimeter protocol (C-20-5) in combination with a database system for analysis single test locations. Methods. One hundred seventy-three ocular hypertensive eyes, 116 "preperimetric" open-angle glaucoma eyes (glaucomatous optic disc atrophy, elevated intraocular pressure, no visual field defects standard white-on-white perimetry), 199 "perimetric" atrophy and defects), 151 control underwent screening conventional perimetry. Four repeated measurements were carried out 15 patients at 2-h intervals judge reproducibility all present strategy begins testing normal 5% probability level. If stimulus is not detected, further targets are presented. FDT-Viewfinder statistics software used case-wise recalculation missed localized levels correlation corresponding locations using Results. Analysis reveals that variation points can be considerable. However, numbers test-stimuli calculated globally or quadrants significantly correlated Octopus (Spearman rank P<0.001). Using predefined specificity 96% 11% 28.5% 86.9% have been classified glaucomatous an overall score consideration different cut-off right left eyes. Conclusion. Point-wise results helpful classification patient groups individual learning curve measurements. C-20-5 able detect considerable proportion patients.

参考文章(33)
Christopher Girkin, Robert N. Weinreb, Pamela A. Sample, Charles F. Bosworth, Eytan Z. Blumenthal, Visual function-specific perimetry for indirect comparison of different ganglion cell populations in glaucoma. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 1783- 1790 ,(2000)
Mansberger S, Cioffi Ga, Johnson C, Spry P, Van Buskirk Em, Frequency doubling perimetry and the detection of eye disease in the community. Transactions of the American Ophthalmological Society. ,vol. 98, pp. 195- ,(2000)
Robert N. Weinreb, Linda M. Zangwill, Cesar Sanchez-Galeana, Christopher Bowd, Cristiana Vasile, Pamela A. Sample, Charles C. Berry, Charles F. Bosworth, Eytan Z. Blumenthal, Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function. Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 1993- 2003 ,(2001)
C A Johnson, S J Samuels, Screening for glaucomatous visual field loss with frequency-doubling perimetry. Investigative Ophthalmology & Visual Science. ,vol. 38, pp. 413- 425 ,(1997)
Algis J. Vingrys, Andrew Turpin, Allison M. McKendrick, Chris A. Johnson, Performance of efficient test procedures for frequency-doubling technology perimetry in normal and glaucomatous eyes. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 709- 715 ,(2002)
C W Tyler, Specific deficits of flicker sensitivity in glaucoma and ocular hypertension. Investigative Ophthalmology & Visual Science. ,vol. 20, pp. 204- 212 ,(1981)
Andrew John Anderson, Chris A. Johnson, Mechanisms isolated by frequency-doubling technology perimetry. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 398- 401 ,(2002)
Jost B. Jonas, Wido M. Budde, Songhomitra Panda-Jonas, Ophthalmoscopic evaluation of the optic nerve head. Survey of Ophthalmology. ,vol. 43, pp. 293- 320 ,(1999) , 10.1016/S0039-6257(98)00049-6
Matthias Korth, Folkert Horn, Brigitte Storck, Jost B. Jonas, Spatial and spatiotemporal contrast sensitivity of normal and glaucoma eyes Graefe's Archive for Clinical and Experimental Ophthalmology. ,vol. 227, pp. 428- 435 ,(1989) , 10.1007/BF02172893
John R Trible, Richard O Schultz, James C Robinson, Terri L Rothe, Accuracy of glaucoma detection with frequency-doubling perimetry. American Journal of Ophthalmology. ,vol. 129, pp. 740- 745 ,(2000) , 10.1016/S0002-9394(00)00354-8