Chromatin and Steroid-Receptor-Mediated Transcription
作者： Catherine E. Watson , Trevor K. Archer
DOI: 10.1007/978-1-4612-1764-0_8
关键词: Cell biology 、 Biology 、 Scaffold/matrix attachment region 、 Pioneer factor 、 Transcription factor 、 Chromatin remodeling 、 Transcription coregulator 、 ChIA-PET 、 Chromatin 、 Eukaryotic transcription
摘要: The normal growth and development of multicellular organisms requires precise spatial temporal regulation gene expression. For a subset genes, steroid nuclear hormone receptors act to modulate transcription by binding hormone-responsive elements (HREs), usually present within the 5’-flanking region gene. Within eukaryotic nucleus these regulatory DNA are associated with histone nonhistone proteins form chromatin. Consequently, thorough mechanistic understanding receptor-mediated must reflect fact that receptors, in concert other factors, on genes highly organized as
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