Inhibition of the growth of malignant mouse lymphoid cells by selenodiglutathione and selenodicysteine
作者： L.N. Vernie , C.J. Homburg , W.S. Bont
DOI: 10.1016/0304-3835(81)90159-2
关键词: Cell number 、 Molecular biology 、 Dye exclusion 、 Trypan blue 、 Selenodiglutathione 、 Selenodicysteine 、 Tumor growth 、 Immunology 、 Ascites 、 Biology 、 Untreated control 、 Cancer research 、 Oncology
摘要: Abstract Intraperitoneal injections of selenodiglutathione (GSSeSG) or selenodicysteine (CySSeSCy) in mice, previously inoculated with tumor cells, inhibited growth and increased the life span treated as compared untreated control mice. Determination cell number at different times after injection GSSeSG CySSeSCy indicated that less cells were present ascites fluid these mice than The trypan blue dye exclusion method performed 1 day showed a high percentage dead (84–99%).
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sci-hub.se 参考文章(12)
C. J. Homburg, W. M. de Bruyn, P. Emmelot, C. J. Bos, Glycolytic and respiratory properties of malignant and nonmalignant lymphoblasts cultured in vitro. Cancer Research. ,vol. 21, pp. 353- 360 ,(1961)
G. Greeder, J. Milner, Factors influencing the inhibitory effect of selenium on mice inoculated with Ehrlich ascites tumor cells Science. ,vol. 209, pp. 825- 827 ,(1980) , 10.1126/SCIENCE.7406957
L. N. Vernie, W. S. Bont, P. Emmelot, Inhibition of in vitro amino acid incorporation by sodium selenite Biochemistry. ,vol. 13, pp. 337- 341 ,(1974) , 10.1021/BI00699A018
L.N. Vernie, W.S. Bont, H.B. Ginjaar, P. Emmelot, Elongation factor 2 as the target of the reaction product between sodium selenite and glutathione (GSSeSG) in the inhibiting of amino acid incorporation in vitro. Biochimica et Biophysica Acta. ,vol. 414, pp. 283- 292 ,(1975) , 10.1016/0005-2787(75)90167-7
George A. Everett, Robert W. Holley, Effect of minerals on amino acid incorporation by a rat-liver preparation Biochimica et Biophysica Acta. ,vol. 46, pp. 390- 391 ,(1961) , 10.1016/0006-3002(61)90766-1
Howard E. Ganther, Reduction of the selenotrisulfide derivative of glutathione to a persulfide analog by glutathione reductase. Biochemistry. ,vol. 10, pp. 4089- 4098 ,(1971) , 10.1021/BI00798A013
Kenneth A. Poirier, John A. Milner, The effect of various seleno-compounds on ehrlich ascites tumor cells. Biological Trace Element Research. ,vol. 1, pp. 25- 34 ,(1979) , 10.1007/BF02783840
C. Y. Hsu, J. A. Milner, Inhibitory Effects of Selenium on the Growth of L1210 Leukemic Cells Cancer Research. ,vol. 41, pp. 1652- 1656 ,(1981)
Mantel N, Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer chemotherapy reports. ,vol. 50, pp. 163- 170 ,(1966)
John L. Kice, Thomas W. S. Lee, Shu-Teh Pan, Mechanism of the reaction of thiols with selenite Journal of the American Chemical Society. ,vol. 102, pp. 4448- 4455 ,(1980) , 10.1021/JA00533A025