Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation.
作者： Hsue-Yin Hsu , Jenq-Jer Yang , Shan-Yeh Lin , Chun-Ching Lin
DOI: 10.1016/S0304-3835(96)04572-7
关键词: Immunocompetence 、 Hedyotis diffusa 、 Spleen 、 Ratón 、 Biological activity 、 Irradiation 、 Chemistry 、 Dose–response relationship 、 Pharmacology 、 Immunology 、 Mechanism of action
摘要: The antitumor effects of two iridoid compounds, geniposidic acid (GA) and geniposide (GP), were investigated in mice along with their possible on radioprotection after sublethal X-irradiation. Decreases the growth implanted tumor by ascitic cells a result intraperitoneal administration GA GP at high concentrated levels. This was achieved exerting levels dosage dose-dependent manner. Except 12th day treatment 500 mg/kg, reduced radiation treated drugs 30 min preirradiated period peripheral leukocytes not observed significantly whole-body And except 7th treatment, when these compounds administered i.p. to before 4 Gy irradiation, neither nor enhanced postirradiation responses splenic blastogenesis PHA. In addition, might be more potent inhibitor than combined X-irradiation, though there no significant synergetic effect activity. preliminary results hematological blastogenic observations this study suggested that they may very well, partially, play role an effective anticancer product ability decrease undesirable damage hematologic tissue dose irradiation.
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sci-hub.se 参考文章(14)
TOHRU ENDO, HEIHACHIRO TAGUCHI, The Constituents of Gardenia jasminoides Geniposide and Genipin-gentiobioside Chemical & Pharmaceutical Bulletin. ,vol. 21, pp. 2684- 2688 ,(1973) , 10.1248/CPB.21.2684
C.-J. Wang, S.-W. Wang, J.-K. Lin, Suppressive effect of geniposide on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Cancer Letters. ,vol. 60, pp. 95- 102 ,(1991) , 10.1016/0304-3835(91)90214-3
Robert I. Mishell, Richard W. Dutton, IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE Journal of Experimental Medicine. ,vol. 126, pp. 423- 442 ,(1967) , 10.1084/JEM.126.3.423
Shinichi Ueda, Yasuhiro Iwahashi, Harukuni Tokuda, Production of anti-tumor-promoting iridoid glucosides in Genipa americana and its cell cultures. Journal of Natural Products. ,vol. 54, pp. 1677- 1680 ,(1991) , 10.1021/NP50078A032
Tong-Ing Ho, Gen-Phon Chen, Yuan-Chuan Lin, Yuh-Meei Lin, Fa-Ching Chen, An anthraquinone from Hedyotis diffusa Phytochemistry. ,vol. 25, pp. 1988- 1989 ,(1986) , 10.1016/S0031-9422(00)81192-9
Shao-Win Wang, Chung-Yih Lai, Chau-Jong Wang, Inhibitory effect of geniposide on aflatoxin B1-induced DNA repair synthesis in primary cultured rat hepatocytes. Cancer Letters. ,vol. 65, pp. 133- 137 ,(1992) , 10.1016/0304-3835(92)90157-Q
Chau-Jong Wang, Chia-Yih Chu, Tsui-Hwa Tseng, Jen-Kun Lin, Penta-acetyl geniposide inhibits the growth and development of C-6 glioma cells in rats Cancer Letters. ,vol. 70, pp. 113- 118 ,(1993) , 10.1016/0304-3835(93)90082-K
H.N. Khastgir, S.K. Sengupta, P. Sengupta, Note on the Constituents of the Indian Medicinal Plant Oldenlandia corymbosa Linn**Received April 4, 1960, from the Research Division, East India Pharmaceutical Works Ltd., Calcutta-34, India. Journal of the American Pharmaceutical Association (Scientific ed.). ,vol. 49, pp. 562- 563 ,(1960) , 10.1002/JPS.3030490821
D. Thierry, P. Gourmelon, C. Parmentier, J.C. Nénot, Haematopoietic Growth Factors in the Treatment of Therapeutic and Accidental Irradiation-induced Bone Marrow Aplasia International Journal of Radiation Biology. ,vol. 67, pp. 103- 117 ,(1995) , 10.1080/09553009514550141
Herman D. Suit, Jens Overgaard, Time-temperature relationship th hyperthermic treatment of malignant and normal tissue in vivo Cancer Research. ,vol. 39, pp. 3248- 3253 ,(1979)