EGFR-expression in primary urinary bladder cancer and corresponding metastases and the relation to HER2-expression. On the possibility to target these receptors with radionuclides

摘要: Background. There is limited effect of tyrosine kinase inhibitors or "naked" antibodies binding EGFR HER2 for therapy metastasized urinary bladder cancer and these methods are therefore not routinely used. Targeting radionuclides to the extracellular domain receptors potentially a better possibility. Methods: EGFR-expression was analyzed in primary tumors corresponding metastases as previously done same patient material results were compared (72 patients). Intracellular mutations since only considered targets intracellular abnormalities should have minor on radiation dose. Results: positive 71% 69% metastases. Local distant EGFR-positive 75% 66% cases, respectively. The expression frequency related lesions slightly higher (data from previous study). expressed 86% cases. co-expression 57% 53% Only 3% 10% negative both metastases, Thus, targeting with might be applied most patients. Conclusions: At least one EGFR- HER2-receptors present cases co-expressed more than half It interesting deliver whole-body receptor-analysis, dosimetry therapy. This can hopefully compensate resistance other therapies patients treated curative instead palliative intention.