Rationale and design of the Left Atrial Appendage Occlusion Study (LAAOS) III

摘要: Background: Occlusion of the left atrial appendage (LAA) is a promising approach to stroke prevention in fibrillation (AF). However, evidence its efficacy and safety date lacking. We herein describe rationale design definitive LAA occlusion trial cardiac surgical patients with AF. Methods: plan randomize 4,700 AF whom on-pump procedure planned undergo or no occlusion. The primary outcome first occurrence systemic arterial embolism over mean follow-up four years. Other outcomes include total mortality, operative (chest tube output post-operative 24 hours, rate re-exploration for bleeding 48 hours post-surgery 30-day mortality), re-hospitalization heart failure, major bleed, myocardial infarction. Results: Left Atrial Appendage Study (LAAOS) III funded vanguard phase by Canadian Institutes Health Research (CIHR), Network Centre Trials Internationally, McMaster University Surgical Associates. As September 9, 2013, 162 have been recruited into study. Conclusions: LAAOS will be largest explore prevention. Its results lead better understanding