Does point-of-care testing lead to the same or better adherence to medication? A randomised controlled trial: the PoCT in General Practice Trial

摘要: OBJECTIVE To compare the clinical effectiveness of point-of-care testing (PoCT) with that pathology laboratory testing, as measured by patients' adherence to medication. DESIGN Multicentre, cluster randomised controlled trial using non-inferiority analysis. Medication was assessed twice (in April 2006 and January 2007) a self-administered questionnaire five-item Adherence Report Scale (MARS-5). SETTING 53 Australian general practices in urban, rural remote areas across three states, September 2005 February 2007. PARTICIPANTS 4968 patients established type 1 or 2 diabetes, hyperlipidaemia, requiring anticoagulant therapy were recruited study. Of these, 4381 included analysis (2585 intervention group 1796 control group). INTERVENTION The (3010 30 practices) had blood urine samples tested PoCT devices within their practices. (1958 23 usual laboratories. MAIN OUTCOME MEASURES proportion responses indicating medication overall condition. RESULTS non-inferior relation (39.3% v 37.0%) (difference, 2.3% [90% CL, - 0.1%, 4.6%]; P < 0.001). Non-inferiority could also be concluded separately for diabetes (38.5% 37.3%) 1.2% -2.5%, 5.0%]; = 0.01); hyperlipidaemia (38.3% 1.0% -1.5%, 3.5%]; 0.001) (44.5% 41.4%) 3.1% -2.1%, 8.3%]; 0.01). CONCLUSIONS Having access immediate test results through is associated same better compared having provided laboratory. used practice can provide practitioners timely complete information, facilitating important self-management behaviours such adherence. TRIAL REGISTRATION Clinical Trials Registry ACTRN 12605000272695.