A Genetically Encodable Ligand for Transfer Hydrogenation
作者： Clemens Mayer , Donald Hilvert
关键词: NAD+ kinase 、 Tripeptide 、 Stereochemistry 、 Foldamer 、 Chemistry 、 Homogeneous catalysis 、 Regioselectivity 、 Formate 、 Transfer hydrogenation 、 Ligand
摘要: Simple tripeptides are shown here to be versatile ligands for iridium-catalyzed transfer hydrogenations affording large acceleration effects. A water-soluble iridium complex with Gly-Gly-Phe, example, catalyzes the reduction of diverse ketones, aldehydes, and imines by formate turnover frequencies rivaling or outperforming those established ligand systems. Regioselective coenzyme NAD+ NADH illustrates potential utility this system biotechnological applications. Because peptides genetically encodable, they represent an attractive class foldamer creating artificial metalloenzymes.
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