Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C–H Activation

作者: T. K. Hyster , L. Knorr , T. R. Ward , T. Rovis

DOI: 10.1126/SCIENCE.1226132

关键词:

摘要: … The substantially increased rate is diagnostic of the key role of the active-site carboxylate in the turnover-limiting step, which we suggest is the C–H activation event. This confirms the …

参考文章(36)
N.M. Green, [74] Spectrophotometric determination of avidin and biotin Vitamins and Coenzymes. ,vol. 18, pp. 418- 424 ,(1970) , 10.1016/0076-6879(71)18342-5
Todd K. Hyster, Tomislav Rovis, Rhodium-Catalyzed Oxidative Cycloaddition of Benzamides and Alkynes via C−H/N−H Activation Journal of the American Chemical Society. ,vol. 132, pp. 10565- 10569 ,(2010) , 10.1021/JA103776U
C. K. Savile, J. M. Janey, E. C. Mundorff, J. C. Moore, S. Tam, W. R. Jarvis, J. C. Colbeck, A. Krebber, F. J. Fleitz, J. Brands, P. N. Devine, G. W. Huisman, G. J. Hughes, Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture Science. ,vol. 329, pp. 305- 309 ,(2010) , 10.1126/SCIENCE.1188934
Daniela Röthlisberger, Olga Khersonsky, Andrew M. Wollacott, Lin Jiang, Jason DeChancie, Jamie Betker, Jasmine L. Gallaher, Eric A. Althoff, Alexandre Zanghellini, Orly Dym, Shira Albeck, Kendall N. Houk, Dan S. Tawfik, David Baker, Kemp elimination catalysts by computational enzyme design Nature. ,vol. 453, pp. 190- 195 ,(2008) , 10.1038/NATURE06879
Tillmann Heinisch, Thomas R Ward, Design strategies for the creation of artificial metalloenzymes. Current Opinion in Chemical Biology. ,vol. 14, pp. 184- 199 ,(2010) , 10.1016/J.CBPA.2009.11.026
Gerard Roelfes, Metallopeptides for Enantioselective Catalysis Chemcatchem. ,vol. 3, pp. 647- 648 ,(2011) , 10.1002/CCTC.201000413
Jérôme Collot, Nicolas Humbert, Myriem Skander, Gérard Klein, Thomas R. Ward, Artificial metalloenzymes for enantioselective catalysis: the phenomenon of protein accelerated catalysis Journal of Organometallic Chemistry. ,vol. 689, pp. 4868- 4871 ,(2004) , 10.1016/J.JORGANCHEM.2004.09.032
Burckhard Seelig, Jack W. Szostak, Selection and evolution of enzymes from a partially randomized non-catalytic scaffold Nature. ,vol. 448, pp. 828- 831 ,(2007) , 10.1038/NATURE06032