Soluble cathepsin K: a novel marker for the prediction of nontraumatic fractures?
作者： Gerold Holzer , Helge Noske , Thomas Lang , Lukas Holzer , Ulrike Willinger
DOI: 10.1016/J.LAB.2005.03.016
关键词: Femoral neck 、 Endocrinology 、 Bone remodeling 、 Cathepsin K 、 Internal medicine 、 Osteopenia 、 Pathology 、 Osteoporosis 、 Alkaline phosphatase 、 Parathyroid hormone 、 Osteocalcin 、 Medicine
摘要: We sought to evaluate serum concentrations of cathepsin K in peripheral blood and determine whether they correlated with bone-mineral density (BMD) the incidence nontraumatic fractures. took samples from 162 patients (101 osteoporosis, 48 osteopenia) 13 healthy controls, then conducted quantitative measurements using a commercially available enzyme-linked immunosorbent assay. Cathepsin were fracture, BMD, markers bone turnover (alkaline phosphatase, bone-specific alkaline osteocalcin, parathyroid hormone, C-telopeptide). The correlations between subjects without fractures those multiple statistically significant (t = −2.1, degrees freedom 107, P .036). levels controls osteoporosis significantly different −3.7, 58.9, p>0.0001) These results suggest that level could serve as marker for fracture prediction BMD.
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