The role of cathepsin K in normal bone resorption.

摘要: Cathepsin K is essential for normal bone resorption; humans lacking cathepsin exhibit pycnodysostosis, which characterized by short stature and osteosclerosis. knockout mice develop osteopetrosis display features characteristic of osteoclasts isolated from these impaired resorption in vitro. Bone depends upon the synthesis its secretion into extracellular compartment at attachment site between surface, wherein organic matrix subsequently degraded K. Factors that directly modulate osteoclastic resorption, including cytokines (RANK ligand, tumor necrosis factor-alpha interferon gamma), hormones (retinoic acid estrogen) nuclear transcriptional factors (c-jun Mitf) also regulate gene expression. Osteoporosis one leading causes morbidity elderly a persistent excess resorption. Therefore, an attractive target therapeutic intervention to prevent ameliorate significant deleterious impact osteoporosis.