Improved survival with pulmonary metastasectomy: An analysis of 1720 patients with pulmonary metastatic melanoma

摘要: Objectives The outcomes of patients with metastatic melanoma are poor. Although prognostic models have been developed to predict the occurrence pulmonary metastasis from cutaneous melanoma, few data exist define these once has occurred. objective this study was discriminate predictors survival for melanoma. Methods We found 1720 listed in a prospective comprehensive cancer center database 14,057 consecutive (Jan 1, 1970–June 2004). Demographic and histopathologic data, time location recurrences, number nodules, subsequent therapies were collected. Univariate multivariate Cox proportional hazards used identify Results median 7.3 months after development metastasis. Significant model included nodular histologic type ( P = .033), disease-free interval .012), presence extrathoracic Conclusions When all other identified risk factors controlled mathematically, metastasectomy maintained significant advantage These support role surgery select subset