Apoptosis, bcl-2 expression, and p53 expression in gastrointestinal stromal/smooth muscle tumors.
作者： Robert E. Cunningham , Susan L. Abbondanzo , Wei-Sing Chu , Theresa S. Emory , Leslie H. Sobin
DOI: 10.1097/00022744-200103000-00005
关键词: Leiomyoma 、 Smooth Muscle Tumor 、 Stromal cell 、 GiST 、 In Situ Nick-End Labeling 、 Cancer research 、 Medicine 、 TUNEL assay 、 Immunohistochemistry 、 Apoptosis
摘要: The authors investigated the relations between outcome and apoptosis, immunohistochemical demonstration of bcl-2 protein, staining for p53 protein in patients with gastrointestinal stromal/smooth muscle tumors (GIST). Patients whose demonstrated cellular apoptosis using terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate-biotin nick end labeling (TUNEL) assay had an improved survival over those did not improve. In contrast, a decreased compared demonstrate bcl-2. There was no relation immunoreactivity survival. These results suggest that inhibition may be associated malignant behavior tumors.
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