Soy Isoflavones—Phytoestrogens and What Else?

摘要: The weak estrogen-like properties of isoflavonoids were discovered over 50 y ago. In recent years, the overall effects isoflavones in soy on human health have been subject lively debate largely based their presumed estrogenic properties. Missing from our knowledge base is systematic identification cellular and biochemical targets mechanisms that they influence. Because benign integrity, a concentration can be reached cell culture models where almost any process modulated. Modern systems biology approaches high dimensional analysis techniques offer new ways to better understand function how cells integrated biological respond compounds such as isoflavones. Data experiments using DNA microarray for examining genistein developing rat uterus indicate alters expression 6-8 times many genes does physiological estrogen 17 beta-estradiol. Although these are exciting, incipient dimensionality places considerable strain quality experimental design meaningful statistical interpretation resulting data. another approach affinity chromatography methods, DING, novel genistein-binding protein yet unknown function, was isolated breast cancer MCF-7 cells. Its remains established.