The GPR54 Gene as a Regulator of Puberty

作者: Stephanie B. Seminara , Sophie Messager , Emmanouella E. Chatzidaki , Rosemary R. Thresher , James S. Acierno

DOI: 10.1097/00006254-200405000-00020

关键词: Accelerated linear growthHypothalamusSexual maturityGeneHormoneEndocrinologySecretionRegulatorInternal medicineMedicine

摘要: The first known step in sexual maturation at puberty is the secretion of gonadotropin-releasing hormone (GnRH) by hypothalamus. Pubertal changes also include accelerated linear growth and adrenal maturation. authors used complementary genetic approaches both humans mice to study a gen

参考文章(1)
Stephanie B. Seminara, Sophie Messager, Emmanouella E. Chatzidaki, Rosemary R. Thresher, James S. Acierno, Jenna K. Shagoury, Yousef Bo-Abbas, Wendy Kuohung, Kristine M. Schwinof, Alan G. Hendrick, Dirk Zahn, John Dixon, Ursula B. Kaiser, Susan A. Slaugenhaupt, James F. Gusella, Stephen O'Rahilly, Mark B.L. Carlton, William F. Crowley, Samuel A.J.R. Aparicio, William H. Colledge, The GPR54 gene as a regulator of puberty The New England Journal of Medicine. ,vol. 349, pp. 1614- 1627 ,(2003) , 10.1056/NEJMOA035322