Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil

摘要: The association between chronic active gastritis and pre-neoplastic conditions as well invasive cancer of the stomach was established several decades ago. risk progression depended on severity distribution gastritis, with cancer, in particular, occurring subjects pan-gastritis. Subsequently, Helicobacter pylori recognised primary cause it demonstrated that pattern corresponded colonisation H . We others then showed both animals humans this associated primarily level acid output.1 2 Although hypothesis widely accepted, led to intense debate when dealing safety long-term treatment profound suppressors. An elegant, long-awaited study from Japan published issue Gut ( see page 624 ) provides compelling evidence depends output influences neoplasia.3 The current based experiments gerbils, one well-established animal models for gastric disease induced by spp.4 Gerbils, used sparingly biomedical research, were first reported a model experimental infection 1991.5 Interestingly, gerbil has been shown …