Cholinergic Interneuron and Parkinsonism
作者： Dario Cuomo , Paola Platania , Giuseppina Martella , Graziella Madeo , Giuseppe Sciamanna
DOI: 10.1007/978-1-60327-252-0_7
关键词: Interneuron 、 Psychology 、 Dopaminergic 、 Striatum 、 Motor learning 、 Synaptic plasticity 、 Cholinergic 、 Neuroscience 、 Parkinsonism 、 Dystonia
摘要: Recent advances in our knowledge of striatal function revealed a previously unexpected role for cholinergic interneurons. The recognition that interneurons are essential synaptic plasticity and motor learning represents significant progress deciphering how the striatum processes cortical inputs, why pathological circumstances cause dysfunction. Loss reciprocal modulation between dopaminergic inputs intrinsic innervation within suitable explanation efficacy anticholinergic drugs both Parkinson’s disease dystonia. These provide exciting indications to underlying circuit alterations. In this chapter, we discuss experimental clinical evidence attempt clarify alterations signalling may contribute dysfunction ultimately identify novel therapeutic strategies fine-tune basal ganglia disorders.
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