bcl-1 rearrangement. Frequency and clinical significance among B-cell chronic lymphocytic leukemias and non-Hodgkin's lymphomas.

摘要: The authors investigated the structural organization of bcl-1 locus, a putative oncogene associated with reciprocal chromosomal translocation t(11;14), by Southern blot hybridization analysis and its frequency, distribution, prognostic significance in panel 156 clinically pathologically well-defined B-cell chronic lymphocytic leukemias (CLLs) non-Hodgkin's lymphomas (NHLs). detected rearrangements only 2 42 CLLs 4 114 NHLs, specifically 3 29 diffuse small 1 10 cleaved cell none 5 intermediate lymphocytic, 13 follicular predominantly cleaved, 17 mixed large cell, 26 noncleaved lymphomas. None seven cases Rai stage III or IV CLL occurring as Richter's syndrome exhibited rearrangements. In conclusion, locus rearranges about 4% is rearranged low-grade neoplasms, does not appear to be preferentially those occasional NHLs displaying clinical aggressiveness, advanced stage, transformation (Richter's syndrome). Therefore demonstration rearrangement have useful significance.