Genotypic characterization of centrocytic lymphoma: frequent rearrangement of the chromosome 11 bcl-1 locus
作者： ME Williams , CD Westermann , SH Swerdlow
DOI: 10.1182/BLOOD.V76.7.1387.1387
关键词: Locus (genetics) 、 Antibody 、 Cytogenetics 、 Gene 、 Gene rearrangement 、 Immunoglobulin light chain 、 Molecular biology 、 Lymphoma 、 Biology 、 Southern blot
摘要: Centrocytic lymphomas are defined in the Kiel classification as B-cell composed exclusively of cells resembling cleaved follicular center (FCC). These have been shown to be histologically, immunophenotypically, and clinically distinct from other FCC lymphomas. DNA 18 centrocytic (14 patients) was analyzed using Southern blotting probes for immunoglobulin heavy (JH) kappa light chain (JK) joining gene, T- cell receptor beta constant gene (CB), bcl-1, bcl-2, c-myc rearrangements. All had JH JK rearrangements, confirming their origin. None specimens detectable CB, or However, 4 14 patients (28.6%) rearrangement chromosome 11 bcl-1 locus. Therefore, genotypically distinguishable majority small by lack demonstrable bcl-2 This supports nature suggests importance putative oncogene these cases. Furthermore, frequent a possible role this locus pathogenesis at least some
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sci-hub.se 参考文章(11)
Michael E Williams, Donald J Innes Jr, Michael J Borowitz, Mark A Lovell, Steven H Swerdlow, Paul E Hurtubise, Russell K Brynes, Wing C Chan, Gerald E Byrne Jr, Clarence C Whitcomb, Christopher Y Thomas, Immunoglobulin and T cell receptor gene rearrangements in human lymphoma and leukemia. Blood. ,vol. 69, pp. 79- 86 ,(1987) , 10.1182/BLOOD.V69.1.79.79
R. B. Mann, E. S. Jaffe, C. W. Berard, Malignant lymphomas--a conceptual understanding of morphologic diversity. A review. American Journal of Pathology. ,vol. 94, pp. 105- 192 ,(1979)
P. G. Pelicci, D. M. Knowles, I. Magrath, R. Dalla-Favera, Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 2984- 2988 ,(1986) , 10.1073/PNAS.83.9.2984
M. L. Cleary, J. Sklar, Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 7439- 7443 ,(1985) , 10.1073/PNAS.82.21.7439
J T Lee, D J Innes, M E Williams, Sequential bcl-2 and c-myc Oncogene Rearrangements Associated with the Clinical Transformation of Non-Hodgkin's Lymphoma Journal of Clinical Investigation. ,vol. 84, pp. 1454- 1459 ,(1989) , 10.1172/JCI114320
Takemi Ohtsuki, Yoshihito Yawata, Hideho Wada, Takashi Sugihara, Masaharu Mori, Masayoshi Namba, Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32). British Journal of Haematology. ,vol. 73, pp. 199- 204 ,(1989) , 10.1111/J.1365-2141.1989.TB00252.X
Yoshihide Tsujimoto, Jorge Yunis, Louise Onorato-Showe, Jan Erikson, Peter C Nowell, Carlo M Croce, Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation Science. ,vol. 224, pp. 1403- 1406 ,(1984) , 10.1126/SCIENCE.6610211
M L Cleary, N Galili, J Sklar, Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. Journal of Experimental Medicine. ,vol. 164, pp. 315- 320 ,(1986) , 10.1084/JEM.164.1.315
E. Athan, D. M. Knowles, D. R. Foitl, bcl-1 rearrangement. Frequency and clinical significance among B-cell chronic lymphocytic leukemias and non-Hodgkin's lymphomas. American Journal of Pathology. ,vol. 138, pp. 591- 599 ,(1991)
Lawrence M. Weiss, Roger A. Warnke, Jeffrey Sklar, Michael L. Cleary, Molecular Analysis of the T(14;18) Chromosomal Translocation in Malignant Lymphomas New England Journal of Medicine. ,vol. 317, pp. 1185- 1189 ,(1987) , 10.1056/NEJM198711053171904