Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation
作者： Yoshihide Tsujimoto , Jorge Yunis , Louise Onorato-Showe , Jan Erikson , Peter C Nowell
关键词:
摘要: The chromosomal breakpoint of chronic lymphocytic leukemia (CLL) cells the B-cell type carrying translocated long arms chromosomes 11 and 14 [t(11;14) (q13;q32)] was cloned. found to be within joining segment human heavy chain locus on arm chromosome 14. A probe that is specific for maps immediately 5' 14q+ isolated. detected a rearrangement homologous genomic DNA in parental CLL also from diffuse large cell lymphoma with t(11;14) translocation. This rearranged not present Burkitt t(8;14) translocation or nonneoplastic lymphoblastoid cells. can thus used identify characterize gene located band q13 appears involved malignant transformation B gene, named bcl -1, unrelated any known retrovirus oncogenes described date.
sciencemag.org
harvard.edu参考文章(13)
H. Van Den Berghe, C. Parloir, G. David, J. L. Michaux, G. Sokal, A new characteristic karyotypic anomaly in lymphoproliferative disorders Cancer. ,vol. 44, pp. 188- 195 ,(1979) , 10.1002/1097-0142(197907)44:1<188::AID-CNCR2820440131>3.0.CO;2-F
M Mercola, X. Wang, J Olsen, K Calame, Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus Science. ,vol. 221, pp. 663- 665 ,(1983) , 10.1126/SCIENCE.6306772
A ar-Rushdi, K Nishikura, J Erikson, R Watt, G Rovera, C. Croce, Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma Science. ,vol. 222, pp. 390- 393 ,(1983) , 10.1126/SCIENCE.6414084
Alain Bernheim, Roland Berger, Gilbert Lenoir, Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocations Cancer Genetics and Cytogenetics. ,vol. 3, pp. 307- 315 ,(1981) , 10.1016/0165-4608(81)90039-X
Jan Norrander, Tomas Kempe, Joachim Messing, Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis. Gene. ,vol. 26, pp. 101- 106 ,(1983) , 10.1016/0378-1119(83)90040-9
GEORGE MANOLOV, YANKA MANOLOVA, Marker band in one chromosome 14 from Burkitt lymphomas. Nature. ,vol. 237, pp. 33- 34 ,(1972) , 10.1038/237033A0
Jan Erikson, Joanne Martinis, Carlo M. Croce, Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature. ,vol. 294, pp. 173- 175 ,(1981) , 10.1038/294173A0
L. Zech, U. Haglund, K. Nilsson, G. Klein, Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with burkitt and non-burkitt lymphomas International Journal of Cancer. ,vol. 17, pp. 47- 56 ,(1976) , 10.1002/IJC.2910170108
C. M. Croce, M. Shander, J. Martinis, L. Cicurel, G. G. D'Ancona, T. W. Dolby, H. Koprowski, Chromosomal location of the genes for human immunoglobulin heavy chains. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 3416- 3419 ,(1979) , 10.1073/PNAS.76.7.3416
A. F. Scott, J. A. Phillips, B. R. Migeon, DNA restriction endonuclease analysis for localization of human beta- and delta-globin genes on chromosome 11. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 4563- 4565 ,(1979) , 10.1073/PNAS.76.9.4563