Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients
作者： Cliff Krein , Markus Thelen , Sabine Grapatin , Stephan Rimpler
DOI:
关键词: Composition (visual arts) 、 Fatty acid 、 Polyol 、 Materials science 、 Organic chemistry 、 Active ingredient 、 Systemic administration
摘要: The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. in particular an injectable composition comprising (a) a ingredient solid phase, (b) vehicle consisting substantially polyol fatty acid esters with degree esterification over 80%, and (c) wetting agent monoester proportion 60%. inventive is used numerous ingredients, whereby ingredients are released from period at least 12, preferably 24 hours.
google.ch 参考文章(222)
Hugo Vanderstichele, Andre Van De Voorde, Eugeen Vanmechelen, Differential diagnosis of neurodegeneration ,(1999)
Kathleen Farinas, Jay Audett, Wendy Putnam, Russell D. Beste, POLYISOBUTYLENE ADHESIVES CONTAINING HIGH Tg TACKIFIER FOR TRANSDERMAL DEVICES ,(1996)
Ronald van der Geest, Meindert Danhof, Harry E. Boddé, Iontophoretic delivery of apomorphine I : In vitro optimization and validation Pharmaceutical Research. ,vol. 14, pp. 1798- 1803 ,(1997) , 10.1023/A:1012100417645
Shivaji Purwar, Sterilization process for pharmaceutical suspensions ,(1997)
Asteria Luzardo‐Alvarez, M. Begoña Delgado‐Charro, José Blanco‐Méndez, Iontophoretic delivery of ropinirole hydrochloride: effect of current density and vehicle formulation. Pharmaceutical Research. ,vol. 18, pp. 1714- 1720 ,(2001) , 10.1023/A:1013322613436
Gevork Minaskanian, James V. Peck, Jonathan Hadgraft, Topical compositions useful as skin penetration barriers ,(1993)
H.E Junginger, Iontophoretic delivery of apomorphine: from in-vitro modelling to the Parkinson patient. Advanced Drug Delivery Reviews. ,vol. 54, pp. 61- 78 ,(2002) , 10.1016/S0169-409X(02)00119-9
Randall P. Sweet, Hot-melt pressure sensitive adhesive article and method of making ,(1988)
Antonin Kozlik, Patricia L. Needham, Bruce J. Sargent, Tetraisoquinoline compounds which have useful pharmaceutical utility ,(1992)
Walter Müller, Use of basic alkali metal salts for manufacturing transdermal therapeutic system ,(1999)