Compositions containing antibodies for treating CD5+ HLA-DR+ B or T cell related diseases
作者： Karine Lester , Martine Cerruti , Severine Loisel , Laurence Boumsell , Christian Berthou
DOI:
关键词: CD5 、 Immunology 、 T cell 、 Graft rejection 、 Antibody 、 Transplantation 、 HLA-DR 、 Lymphoma 、 Biology
摘要: The present invention relates to compositions containing antibodies for treating CD5+ HLA-DR+ B OR T cell related diseases such as or malignances (leukaemia and lymphoma), autoimmune transplantation graft rejection.
lens.org 参考文章(7)
Uwe Marx, Marco Riedel, Christoph Giese, Hikmat Bushnaq-Josting, Artificial immune organ ,(2004)
Hélène Gary-Gouy, Alexander Sainz-Perez, Jean-Brice Marteau, Anne Marfaing-Koka, Jozo Delic, Hélène Merle-Beral, Pierre Galanaud, Ali Dalloul, Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. Journal of Immunology. ,vol. 179, pp. 4335- 4344 ,(2007) , 10.4049/JIMMUNOL.179.7.4335
Roberto De Pascalis, Makoto Iwahashi, Midori Tamura, Eduardo A. Padlan, Noreen R. Gonzales, Ameurfina D. Santos, Mariateresa Giuliano, Peter Schuck, Jeffrey Schlom, Syed V. S. Kashmiri, Grafting of “Abbreviated” Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody The Journal of Immunology. ,vol. 169, pp. 3076- 3084 ,(2002) , 10.4049/JIMMUNOL.169.6.3076
Zhengxing Qu, Chien-Hsing Chang, Hans J. Hansen, David M. Goldenberg, Humanized l243 antibodies ,(2006)
S. Rudikoff, A. M. Giusti, W. D. Cook, M. D. Scharff, Single amino acid substitution altering antigen-binding specificity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 1979- 1983 ,(1982) , 10.1073/PNAS.79.6.1979
Robert M. MacCallum, Andrew C.R. Martin, Janet M. Thornton, Antibody-antigen Interactions: Contact Analysis and Binding Site Topography Journal of Molecular Biology. ,vol. 262, pp. 732- 745 ,(1996) , 10.1006/JMBI.1996.0548