Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
作者： Eun-ok Im , Yung Hyun Choi , Kee-Joo Paik , Hongsuk Suh , Youngeup Jin
DOI: 10.1016/S0304-3835(00)00671-6
关键词: Retinoblastoma protein 、 Cancer research 、 Bile acid 、 Cell cycle 、 Cyclin D3 、 Apoptotic nuclear changes 、 Ursodeoxycholic acid 、 Biology 、 Chenodeoxycholic acid 、 Cancer cell
摘要: We have compared the anti-proliferative effects of ursodeoxycholic acid (UDCA), chenodeoxycholic (CDCA) and their derivatives, HS-1183, HS-1199 HS-1200, on MCF-7 (wild-type p53) MDA-MB-231 (mutant cells. While UDCA CDCA exhibited no significant effect, novel derivatives inhibited proliferation both cell lines in a concentration-dependent manner, concomitant with apoptotic nuclear changes increase sub-G1 population DNA fragmentation. Furthermore, we also observed an ratio pro-apoptotic protein Bax to anti-apoptotic Bcl-2 cleavages lamin B poly(ADP-ribose) polymerase (PARP) Cell cycle related proteins, cyclin D1 D3, as well retinoblastoma (pRb) were down-regulated, while level cyclin-dependent kinase inhibitor p21(WAF1/CIP1) was increased cancer cells after treatment bile acids. These findings suggest that these cytotoxic human breast carcinoma mediated via apoptosis through p53-independent pathway.
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