Synthetic chenodeoxycholic acid derivatives inhibit glioblastoma multiform tumor growth in vitro and in vivo.
作者： Soo Jin Baek , Bong Soo Park , Jae Hong Kim , Young Hyun Yoo , Yoon Cheong Kim
DOI: 10.3892/IJO.27.3.653
关键词:
摘要: We previously reported that the synthetic chenodeoxycholic acid (CDCA) derivatives showed apoptosis-inducing activity on various cancer cells in vitro. This study was undertaken to explore whether CDCA derivatives, HS-1199 and HS-1200, had an anticancer effect malignant glioblastoma cells. administered them culture U-118MG, U-87MG, T98G, U-373MG The tested several lines of apoptotic manifestations, such as activation caspase-3, degradation DFF, production poly(ADP-ribose) polymerase cleavage, nuclear condensation, inhibition proteasome activity, reduction mitochondrial membrane potential release cytochrome c cytosol translocation AIF nuclei. Between two HS-1200 a stronger than HS-1199. In vivo efficacy U87MG inoculated into non-obese diabetic severe combined immunodeficient (NOD/SCID) mice. treatment significantly inhibited increase tumor size NOD/SCID mice prolonged life spans. supports possibility chemotherapeutic agent.
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