Repair efficiency and PUVA therapeutic response variation in patients with vitiligo
作者： Surekha Tippisetty , Deepthi Goudi , Abdul Waheed Mohammed , Parveen Jahan
DOI: 10.1016/J.TIV.2012.08.003
关键词: DNA damage 、 Dermatology 、 Psoralen 、 Ultraviolet A Radiation 、 Genotoxicity 、 Vitiligo 、 In patient 、 Drug response 、 Biology 、 Depigmentation
摘要: Abstract Vitiligo is an acquired depigmentation disorder affecting 0.1% to >8.8% in Indian population. Psoralen and ultraviolet A radiation (PUVA) a gold standard treatment for vitiligo, however, response still empirical. In order investigate whether drug variation influenced by the repair ability of PUVA treated vitiligo subjects, single cell gel electrophoresis (SCGE) genotoxicity serum malonaldehyde (MDA) cytotoxicity were performed on 107 subjects (77 cases 30 healthy controls) South vitro was assessed considering residual damage. significant difference observed between patients controls with regard their mean values DNA damage MDA levels (p
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Francis P. Gasparro, The Role of PUVA in the Treatment of Psoriasis American Journal of Clinical Dermatology. ,vol. 1, pp. 337- 348 ,(2000) , 10.2165/00128071-200001060-00002
Ozer Arican, Ergül Belge Kurutas, Oxidative stress in the blood of patients with active localized vitiligo. Acta dermatovenerologica Alpina, Pannonica, et Adriatica. ,vol. 17, pp. 12- 16 ,(2008)
Asem Alkhateeb, Pamela R. Fain, Anthony Thody, Dorothy C. Bennett, Richard A. Spritz, Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Research. ,vol. 16, pp. 208- 214 ,(2003) , 10.1034/J.1600-0749.2003.00032.X
H.A. Nadiger, C.A. Mathew, B. Sadasivudu, Serum malanodialdehyde (TBA reactive substance) levels in cigarette smokers Atherosclerosis. ,vol. 64, pp. 71- 73 ,(1987) , 10.1016/0021-9150(87)90056-6
S NADIN, L VARGASROIG, G DRAGO, J IBARRA, D CIOCCA, DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: a pilot study on the implications in the clinical response to chemotherapy Cancer Letters. ,vol. 239, pp. 84- 97 ,(2006) , 10.1016/J.CANLET.2005.07.025
T. Surekha, M. Ishaq, K.P. Latha, P.H. Rao, P. Jahan, Do Clinical Variants of Vitiligo Involve X-Chromosomal Gene(s) Too? Journal of Medical Sciences(faisalabad). ,vol. 8, pp. 728- 733 ,(2008) , 10.3923/JMS.2008.728.733
Sophie Couvé, Gaëtane Macé-Aimé, Filippo Rosselli, Murat K. Saparbaev, The Human Oxidative DNA Glycosylase NEIL1 Excises Psoralen-induced Interstrand DNA Cross-links in a Three-stranded DNA Structure Journal of Biological Chemistry. ,vol. 284, pp. 11963- 11970 ,(2009) , 10.1074/JBC.M900746200
Z Zarebska, E Waszkowska, S Caffieri, F Dall'Acqua, PUVA (psoralen + UVA) photochemotherapy: processes triggered in the cells. Farmaco. ,vol. 55, pp. 515- 520 ,(2000) , 10.1016/S0014-827X(00)00076-8
JOSEPH G. MORELLI, DAVID A. NORRIS, TATSUYA HORIKAWA, Melanocyte Destruction and Repopulation in Vitiligo Pigment Cell Research. ,vol. 7, pp. 193- 203 ,(1994) , 10.1111/J.1600-0749.1994.TB00049.X
Lisa Giovannelli, Serena Bellandi, Vanessa Pitozzi, Paolo Fabbri, Piero Dolara, Silvia Moretti, Increased oxidative DNA damage in mononuclear leukocytes in vitiligo Mutation Research. ,vol. 556, pp. 101- 106 ,(2004) , 10.1016/J.MRFMMM.2004.07.005