Medial temporal lobe structures and hippocampal subfields in psychotic disorders: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study.

摘要: Importance Structural alterations in the hippocampus and other medial temporal lobe regions have been observed schizophrenia. How these hippocampal subfields might differ across psychosis spectrum remains unclear. Objectives To characterize structures, including subfields, using magnetic resonance imaging to examine their relation cognitive function spectrum. Design, Setting, Participants Case-control, cross-sectional neuroimaging study a large series of probands with psychotic disorders healthy volunteers as part Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). Patients (schizophrenia, n = 219; schizoaffective disorder, n = 142; bipolar n = 188) controls (n = 337) were recruited ambulatory clinics at university health centers B-SNIP consortium. Main Outcomes Measures Medial quantified an automated parcellation approach FreeSurfer software. Memory parameters assessed standardized neuropsychological tests. Results Hippocampal volume reductions seen all 3 diagnostic groups when compared controls; entorhinal cortex parahippocampal limited schizophrenia ( P Conclusions Relevance Alterations evident disorders. that participate memory-related processes supporting pattern separation completion be abnormal may underlie pathophysiology psychosis.