Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study.

摘要: Background Previous reports of ventricular and hippocampal volumes in patients with bipolar disorder (BP) have been inconsistent their findings. One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests psychotic (PBP) nonpsychotic (NPBP) forms BP two subtypes might differ pathophysiology. Methods We investigated 38 adults clearly defined PBP (n = 23) NPBP subtypes, compared 33 persons schizophrenia (SZ) 44 healthy community control subjects (HC). Ventricular were reliably measured on high-resolution anatomic magnetic resonance imaging scans. used a multivariate analysis covariance to compare across groups, covarying for total brain volume. Potential effects illness features explored, contrasting NPBP. Results For but not regions, we found significant volume difference HC (p Conclusions These results suggest associated increased ventricle trend toward smaller left volumes, as observed SZ.